Informative nucleic arrays and methods for making same

Details Informative nucleic arrays and methods for making same Informative nucleic arrays and methods for making same

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2397391

The present invention is directed to methods for making and using informative nucleic acid arrays (e.g., DNA including cDNA, RNA, PNA) for research and other applications in various disciplines or areas of interest. Examples of such disciplines include, without limitation, dermatology, pharmacology, toxicology, oncology, gynecology, urology, gastroenterology, as well as studies of sentinel gene discovery, signature gene discovery, mechanism of action, drug screening, drug metabolism, etc. The informative nucleic acid arrays of the present invention may contain only the gene sequences that are of interest in a particular area of interest or application and may exclude other gene sequences.

La présente invention concerne des méthodes de production et d'utilisation de jeux ordonnés d'échantillons nucléiques informatifs (p. ex. l'ADN comprenant l'ADNc, l'ARN, le PNA) destinés à la recherche ou à d'autres applications se rapportant à diverses disciplines ou domaines d'intérêt. Des exemples de telles disciplines comprennent, entre autres, la dermatologie, la pharmacologie. la toxicologie, l'oncologie, la gynécologie, l'urologie, la gastroentérologie, ainsi que l'étude de la découverte de gènes sentinelles, de la découverte de gènes signature, du mécanisme de l'action, du dépistage systématique des drogues, du système de métabolisation des médicaments, etc. Les jeux ordonnés d'échantillons nucléiques informatifs de l'invention ne peuvent contenir que des séquences génétiques présentant un intérêt pour un domaine d'intérêt particulier ou une application particulière, à l'exclusion éventuelle d'autres séquences génétiques.

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