Infrared spectroscopy of a sample treated with preservative

Details Infrared spectroscopy of a sample treated with preservative Infrared spectroscopy of a sample treated with preservative

G - Physics

01

N

G01N 21/35 (2006.01)

Patent

CA 2192648

The presence of anomalies in biological tissue and cells in natural or cultured form (e.g. cancerous tissue or cells) is detected by directing a beam of infrared light at a preservative treated sample, prepared from fresh biological tissue or cells, in either the transmission mode or the Attenuated Total Reflectance (ATR) mode. The anomaly is then determined by whether changes in infrared absorption have occurred, due to the vibration of at least one functional group of molecules present in the sample, which are characteristic of the anomaly. The preservative may be an aqueous solution of formalin, an aqueous solution of ethyl alcohol, or an aqueous solution of inorganic salts. The preservative treatment prevents degradation of the sample at room temperature which has been found to change the infrared absorption characteristics which can lead to misinterpretations.

On détecte la présence d'anomalies dans des tissus biologiques et dans des cellules naturelles ou cultivées (par exemple cellules ou tissu cancéreux) en dirigeant un faisceau de lumière IR sur un échantillon traité par un agent de conservation, et préparé à partir de cellules biologiques ou de tissus frais. L'examen se fait soit en transmission soit en utilisant un dispositif ATR. L'anomalie est déterminée à partir de changements constatés dans le spectre IR dus au moins à un groupe fonctionnel présent dans l'échantillon et caractéristiques de l'anomalie. L'agent de conservation peut être une solution aqueuse de formol, une solution aqueuse d'alcool éthylique ou une solution aqueuse de sels minéraux. Le traitement par l'agent de conservation empêche la dégradation de l'échantillon à température ambiante, laquelle dégradation change les caractéristiques d'absorption et peut conduire à des erreurs d'interprétation.

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