A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
402/2, 167/206
A61K 31/785 (2006.01)
Patent
CA 2038852
The invention is concerned with novel ingestible cross-linked homopolymers having functional groups consisting of linear or branched amines, of the formula: P-[NR(CH2)n ]mN(R)2 or Image (Ia) (Ib) and their pharmaceutically acceptable salts of the formulae: P-[N+(R)2(CH)n]MN+(R)3(m+l)X- (Ic) and Image (Id) wherein P represents a hydrophobic, cross-linked and non- digestible homopolymer backbone; R is a hydrogen atom or a lower alkyl radical; X- is a pharmaceutically acceptable anion; m is an integer varying from 1 to 6 inclusive; and n, o and p are, independently, integers varying from 2 to 12 inclusive. The amine functionalized and cross-linked homo- polymers of the invention are highly efficient adsorbents for bile acids and salts and can thus be used for reducing hypercholesterolemia in affected humans.
Brown George Ronald
St. Pierre Leon Edward
Wu Gaoming
Lowchol Scientific Inc.
Swabey Ogilvy Renault
LandOfFree
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