Ingestible device for the release of substances at distinct...

Details Ingestible device for the release of substances at distinct... Ingestible device for the release of substances at distinct...

A - Human Necessities

61

B

A61B 5/00 (2006.01) A61B 5/07 (2006.01) A61M 31/00 (2006.01)

Patent

CA 2390153

The field of the invention is site-specific drug delivery capsules (SSDC's). The disclosure relates to a closure member (14) for a substance reservoir (12) of an SSDC (10). The SSDC (10) includes a retainer that provides a non-linear force resisting opening of the closure member (14). The non-linear force ensures that the closure member (14) unseals the reservoir (12) only when an opening force exceeds a maximal value of the resisting force, thereby preventing premature or accidental emptying of the reservoir (12). The preferred means of providing the resistive force is a rolling, elastomeric o-ring (64) that additionally seals the closure member (14) into an aperture (13).

L'invention concerne des capsules permettant d'administrer localement un médicament (capsule SSD). Le mode de réalisation décrit dans la présente invention consiste en un élément de fermeture (14) pour réservoir à substance (12) d'une capsule SSD (10). Cette capsule (10) comprend une bague d'arrêt fournissant une force non-linéaire résistant à l'ouverture de l'élément de fermeture (14). La force non-linéaire permet de garantir l'ouverture de l'élément de fermeture (14) seulement lorsqu'une force d'ouverture est supérieure à une valeur maximale de la force de résistance; ce qui permet d'empêcher que ledit réservoir (12) ne se vide prématurément ou accidentellement. Le moyen optimal permettant de fournir la force de résistance consiste en un joint torique (64) élastomère à roulement, lequel scelle également l'élément de fermeture (14) dans une ouverture (13).

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