Ingestible hydrophilic polymeric amines useful for lowering...

Details Ingestible hydrophilic polymeric amines useful for lowering... Ingestible hydrophilic polymeric amines useful for lowering...

C - Chemistry, Metallurgy

08

F

402/2, 167/206

C08F 8/32 (2006.01) A61K 31/785 (2006.01) C08F 8/44 (2006.01)

Patent

CA 1335142

The invention is concerned with swellable, covalently cross-linked amine homopolymers having the formula: P-[(CH2)nNR]mR or Image (Ia) (Ib) and pharmaceutically acceptable salts thereof having the formulae: P-[(CH2)nN+(R)2]m R.mX- (Ic) and Image (Id) wherein P represents a hydrophilic, covalently cross-linked and non-digestible homopolymer backbone; R is a hydrogen atom or a lower alkyl radical; X- is a pharmaceutically acceptable anion; m is an integer varying from 1 to 10 inclusive; and n, o and p are, independently, integers varying from 2 to 12 inclusive. The covalently cross-linked amine homopolymers of the invention are highly efficient adsorbents for bile acids and salts and can thus be used for reducing hypercholesterolemia in affected humans.

606027

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