Ingestible polymeric phosphonium salts for the lowering of...

Details Ingestible polymeric phosphonium salts for the lowering of... Ingestible polymeric phosphonium salts for the lowering of...

C - Chemistry, Metallurgy

08

G

C08G 83/00 (2006.01) A61K 31/80 (2006.01) C08F 8/40 (2006.01)

Patent

CA 2063499

The invention is concerned with novel ingestible polymeric phosphonium salts having the formulas: P'-t(CH2)n1P+(R)2]m1[(CH2)n2P+(R)2]m2R(m1+m2)X- (Ia) Image (Ib) or Image (Ic) wherein P' represents a cross-linked and non-digestible polymer backbone; R is a lower alkyl radical; X- is a pharmaceutically acceptable anion; m1 and m2 are, independently, integers varying from 0 to 5 inclusive, with the proviso thatin formula (Ia) ml + m2 1; n, n1 and n2 are, independently, integers varying from 0 to 6 inclusive, with the proviso that when m1 1, n2 1; and o1, o2, P1 P2, q1 and q2 are, independently, integers varying from 1 to 6 inclusive. The polymeric phosphonium salts of the invention are highly efficient sorbents for bile acids and salts and can thus be used for reducing hypercholesterolemia in affected humans.

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