Inhalable aztreonam lysinate formulation for treatment and...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2530774

A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a concentrated formulation of aztreonam lysinate delivered as an aerosol or dry powder formulation. A process for manufacturing aztreonam lysinate.

L'invention concerne un procédé et une composition pour le traitement d'infections bactériennes pulmonaires, causées par des bactéries gram-négatif, convenant pour le traitement d'infections causées par <i>Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter </i>species<i>, Serratia marcescens</i>, ainsi que les infections causées par <i>Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, </i> et <i>Pseudomonas aeruginosa</i> résistant à de multiples médicaments, au moyen d'une formulation concentrée d'aztréoname lysinate administrée sous forme d'aérosol ou d'une formulation en poudre anhydre. L'invention concerne en outre un procédé de fabrication d'aztréoname lysinate.

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