Inhalable formulations for treating pulmonary hypertension...

A - Human Necessities – 61 – K

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A61K 9/12 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2530632

The present invention is directed to an inhalable formulation for the treatment of pulmonary hypertension in a mammal (e.g., humans), wherein the formulation comprises at least one hypertension reducing agent, including but not limited to an angiotensin converting enzyme inhibitor, angiotensin receptor blocker, beta-blocker, calcium-channel blocker or vasodilator, or any combination thereof. The formulations of the present invention may be a solution or suspension, and preferably are suitable for administration via nebulization. The present invention is also directed to a method and kit for treating a mammal suffering from pulmonary hypertension.

Préparation inhalable destinée à traiter l'hypertension pulmonaire chez un mammifère (par ex. un être humain), qui contient au moins un agent hypotenseur, dont, entre autres, un inhibiteur de l'enzyme de conversion de l'angiotensine, un bloqueur du récepteur de l'angiotensine, un bêtabloquant, un bloqueur du canal calcique ou un vasodilatateur ou une combinaison quelconque de ces substances. Les préparations selon la présente invention peuvent être une solution ou une suspension, et sont de préférence adaptées pour l'administration par nébulisation. La présente invention concerne également un procédé et un kit de traitement de mammifères souffrant d'hypertension pulmonaire.

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