Inhalant containing modified superoxide dismutase

Details Inhalant containing modified superoxide dismutase Inhalant containing modified superoxide dismutase

A - Human Necessities

61

K

A61K 38/44 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61K 47/26 (2006.01) A61K 47/48 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2745411

Disclosed is an inhalant particularly for treating idiopathic (acute) or chronic interstitial pneumonia, which comprises, as an active ingredi-ent, a lecithin-bound superoxide dismutase (PC--SOD) that can exert the activity of a superoxide dis-mutase (SOD) efficiently. Specifically disclosed is an inhalant characterized by comprising, as an active ingredient, a PC-SOD represented by general formu-la (I): SOD'(Q-B)m (I) (In the formula, SOD' repre-sents a residue of a superoxide dismutase; Q repre-sents a chemical cross-linkage; B represents a residue produced by removing an hydrogen atom from a hydroxy group in lysolecithin having the hy-droxy group at position-2 in a glycerol moiety there-of; and m represents an average number of lysolecithin molecules bound to one superoxide dis-mutase molecule and is an integer of 1 or greater.)

La présente invention concerne un inhalant en particulier pour traiter une pneumonie interstitielle idiopathique (aiguë) ou chronique, qui comprend, en tant que substance active, une superoxyde dismutase liée à la lécithine (PC-SOD) qui peut exercer lactivité dune superoxyde dismutase (SOD) efficacement. La présente invention concerne spécifiquement un inhalant caractérisé en ce quil comprend, en tant que substance active, une PC-SOD représentée par la formule générale (I) : SOD'(Q-B)m (I) (Dans la formule, SOD' représente un résidu de superoxyde dismutase ; Q représente une réticulation chimique ; B représente un résidu produit par élimination dun atome dhydrogène dun groupe hydroxy dans la lysolécithine ayant le groupe hydroxy à la position-2 dans un fragment glycérol de celle-ci ; et m représente un nombre moyen de molécules de lysolécithine liées à une molécule de superoxyde dismutase et est un entier de 1 ou plus.)

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