Inhalant formulation containing sulfoalkyl ether...

A - Human Necessities – 61 – K

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Details

A61K 47/40 (2006.01) A61K 31/56 (2006.01) A61K 31/573 (2006.01) A61K 31/58 (2006.01) A61P 11/00 (2006.01) C08B 37/16 (2006.01) C08L 5/16 (2006.01)

Patent

CA 2656318

An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.

La présente invention concerne une formulation pour inhalation à base de cyclodextrine sulfoalkyl-éther (SAE-CD) et de corticostéroïde. Cette formulation convient à l'administration à un sujet par nébulisation au moyen de tous modèles connus de nébuliseur. La formulation peut être inclue dans un nécessaire. La formulation s'administre en solution aqueuse, mais elle peut également se conserver en poudre sèche, en solution prête à l'emploi ou en composition concentrée. Cette formulation s'emploie dans un système amélioré de nébulisation pour l'administration de corticostéroïde par inhalation. La SAE-CD présente dans la formulation augmente de façon notable la stabilisé chimique du budésonide. L'invention concerne également un procédé d'administration de la formulation par inhalation. La formulation convient également à l'administration par voie nasale au moyen d'appareils conventionnels.

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