Inhalant formulation containing sulfoalkyl ether...

A - Human Necessities – 61 – K

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A61K 9/12 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2551749

An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.

L'invention concerne une formulation à inhaler contenant du SAE-CD et un corticostéroïde, cette formulation étant conçue pour l'administration à un sujet par nébulisation au moyen d'un nébuliseur usuel et pouvant être contenue dans un kit. La formulation est administrée sous forme de solution aqueuse, mais elle peut être stockée sous forme de poudre sèche, de solution prête à l'emploi ou de composition concentrée. Ladite formulation est utilisée dans un système de nébulisation perfectionné pour l'administration d'un corticostéroïde par inhalation. Le SAE-CD présent dans la formulation améliore notablement la stabilité chimique du budésonide. La présente invention porte également sur une méthode pour administrer la formulation par inhalation, laquelle formulation peut également être administrée au moyen d'un appareil classique d'administration nasale.

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