Inhalation compositions

Details Inhalation compositions Inhalation compositions

A - Human Necessities

61

K

A61K 31/65 (2006.01) A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61K 31/045 (2006.01) A61K 31/075 (2006.01) A61K 31/135 (2006.01) A61K 31/56 (2006.01) A61K 47/26 (2006.01) A61L 9/04 (2006.01)

Patent

CA 2499273

The invention provides a dry powder inhalation composition comprising medicament particles and a mixture of lactose particles with a VMD of between about 70 and about 120 microns and a diameter of less than 250 microns, the mixture being characterized in that up to 96% by weight of the lactose particles are less than 150 microns in diameter and wherein up to 25% by weight of the lactose particles are less than 5 microns in diameter. The compositions provide for a more accurate, uniform and consistent dispersion when used with, for example, a multidose dry powder inhaler. Also disclosed are methods for use of the compositions of the invention.

L'invention porte sur une composition à inhaler de poudre sèche contenant des particules de médicament et un mélange de particules de lactose avec diamètre volumétrique moyen compris entre environ 70 et 120 microns et un diamètre inférieur à 250 microns. Le mélange se caractérise par le fait que jusqu'à 96 % en poids des particules de lactose possèdent un diamètre inférieur à 150 microns, 25 % en poids des particules de lactose ont un diamètre inférieur à 5 microns. Ces compositions fournissent une dispersion plus précise, uniforme et régulière lorsqu'elles sont utilisées par exemple avec un inhalateur de poudre sèche. L'invention concerne aussi des procédés d'utilisation des compositions susmentionnées.

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