Inhalation particles incorporating a combination of two or...

A - Human Necessities – 61 – K

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A61K 9/72 (2006.01) A61K 9/14 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/57 (2006.01) A61K 31/573 (2006.01) A61K 45/06 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2424620

Crystalline spherical inhalation particles incorporating a combination of two or more different active ingredients and a process for the preparation thereof are disclosed. The particles have narrow particle size distribution, rough surfaces and improved stability. The inhalation particles of the invention are particularly useful in the administration of a combination medicament, e.g. a combination of an anti-inflammatory agent and a bronchodilator, by inhalation in the treatment of asthma and other respiratory disorders.

La présente invention concerne des particules d'inhalation sphériques et cristallines comprenant une combinaison de deux principes actifs différents et un processus de préparation de ces particules. Ces particules présentent une répartition de tailles de particule étroite, des surfaces rugueuses et une stabilité améliorée. Les particules d'inhalation de cette invention conviennent particulièrement pour l'administration d'un médicament de combinaison, par exemple une combinaison d'un agent anti-inflammatoire et d'un bronchodilatateur, par inhalation dans le cadre du traitement de l'asthme ou d'autres troubles respiratoires.

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