Inhaleable spray dried 4-helix bundle protein powders having...

Details Inhaleable spray dried 4-helix bundle protein powders having... Inhaleable spray dried 4-helix bundle protein powders having...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2418960

The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery o the lungs. The powders of the invention are produced by spray drying a 4 .alpha.-helix bundle protein under conditions which both: (i) protect th eprotein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).

La présente invention concerne des compositions de poudres hautement dispersables séchées par atomisation, et précisément, des compositions de poudres à inhaler séchées par atomisation conçues pour une administration pulmonaire en aérosol. Ces poudres sont obtenues par séchage par atomisation d'une protéine en faisceau à quatre hélices .alpha. dans des conditions qui, à la fois: (a) protègent la protéine de l'agrégation, et (b) permettent d'obtenir des particules convenant à l'inhalation (autrement dit, qui présentent une efficacité d'aérosol supérieure).

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