Inhibiting bone resorption

Details Inhibiting bone resorption Inhibiting bone resorption

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 31/00 (2006.01) A61K 31/663 (2006.01) A61K 45/00 (2006.01) A61P 1/04 (2006.01) A61P 3/14 (2006.01) A61P 13/08 (2006.01) A61P 19/00 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2294595

Disclosed are methods for inhibiting bone resorption in mammals while minimizing the occurrence of or potential for adverse gastrointestinal effects. Also disclosed are pharmaceutical compositions and kits for carrying out the therapeutic methods disclosed herein. The compounds are bisphosphonates selected from the group consisting of alendronate, cimadronate, clodronate, tiludronate, etridronate, ibandronate, risedronate, piridronate, pamidronate, zolendronate, optionally in combination with a histamine H2 antagonist.

L'invention concerne des procédés d'inhibition de résorption osseuse chez les mammifères tout en minimisant l'apparition ou le risque d'effets secondaires gastro-intestinaux. Font aussi l'objet de cette invention les compositions pharmaceutiques et les ensembles permettant de mettre en oeuvre les procédés thérapeutiques.

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