Inhibiting hepatitis c virus processing and replication

Details Inhibiting hepatitis c virus processing and replication Inhibiting hepatitis c virus processing and replication

A - Human Necessities

61

K

A61K 39/00 (2006.01) A01N 43/40 (2006.01) A01N 43/42 (2006.01) A61K 31/00 (2006.01) A61K 31/365 (2006.01) A61K 31/395 (2006.01) A61K 39/385 (2006.01)

Patent

CA 2416603

The present invention features methods for inhibiting HCV replication and processing by targeting heat shock protein 90 (HSP90). HSP90 is a cellular chaperone protein that was found to be an essential factor in NS2/3 self- cleavage. HSP90 can be targeted using compounds inhibiting the ability of HSP90 to facilitate NS2/3 cleavage.

L'invention concerne des procédés permettant d'inhiber la réplication et la maturation de HCV par ciblage d'une protéine de stress 90 (HSP90). HSP90 est une protéine chaperonne cellulaire dont on a découvert qu'elle constitue un facteur essentiel de l'auto-clivage de NS2/3. HSP90 peut être ciblée au moyen de composés inhibant la capacité de HSP90 à faciliter le clivage de NS2/3.

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