Inhibiting peptides having a dihydroxyethylene isostere...

Details Inhibiting peptides having a dihydroxyethylene isostere... Inhibiting peptides having a dihydroxyethylene isostere...

C - Chemistry, Metallurgy

07

K

260/314, 530/5.0

C07K 5/02 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 401/12 (2006.01)

Patent

CA 1309555

ABSTRACT The present invention provides novel renin-inhibiting peptides of the formula X-A6-B7-C8-D9-E10-F11-G12-H13-I14-Z. wherein the E10-F11 moiety is a dihydroxyethylene isostere, X and Z are terminal groups, and the remaining variables are absent or are amino acid residues. Such inhibitors are useful for the control of hypertension.

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