Inhibiting protein interactions

Details Inhibiting protein interactions Inhibiting protein interactions

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) C07K 1/22 (2006.01) C07K 4/00 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/82 (2006.01) C12N 9/12 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2163905

Disclosed is a method of evaluating an anti-proliferative compound by contacting the compound with a Raf and determining its ability to bind to Ras, and methods of inhibiting cell poliferation in an animal by administering a compound which reduces the interaction of Ras with Raf.

Procédé d'évaluation d'un composé antiprolifératif par sa mise en contact avec un Raf et par la détermination de sa capacité à se lier au Ras ainsi que procédés d'inhibition de la prolifération cellulaire chez un animal par l'administration d'un composé qui réduit l'interaction du Raf avec le Ras.

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