Inhibiting protein interactions

Details Inhibiting protein interactions Inhibiting protein interactions

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 38/06 (2006.01) A61K 38/08 (2006.01) C07K 14/82 (2006.01) C12N 9/12 (2006.01) C12Q 1/18 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2248998

The invention discloses methods of inhibiting direct binding of Ras with Raf and screening methods to identify compounds which inhibit direct binding of Ras to Raf, Raf activation, and cell proliferation.

La présente invention concerne un procédé permettant d'inhiber la liaison directe des gènes Ras avec les gènes Raf. L'invention concerne également des procédés de criblage permettant d'identifier des composés inhibiteurs de la liaison directe des gènes Ras avec les gènes Raf, inhibiteurs de l'activation des gènes Raf et inhibiteurs de la prolifération cellulaire.

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