Inhibiting the development of tolerance to and/or dependence...

Details Inhibiting the development of tolerance to and/or dependence... Inhibiting the development of tolerance to and/or dependence...

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 31/33 (2006.01) A61K 31/54 (2006.01)

Patent

CA 2113515

Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or 'that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM1 or GT1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.

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