A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/715 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/28 (2006.01) A61K 38/39 (2006.01) C07K 16/22 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2124591
2124591 9310808 PCTABS00022 The present invention provides a method for treating or arresting the progress of pathologies characterized by an accumulation of extracellular matrix components by providing an agent to suppress the activity of transforming growth factor .beta. (TGF-.beta.) a peptide growth factor which is anabolic and leads to fibrosis and angiogenesis. Pathologies which can be so treated include the various fibrotic diseases such as fibrotic cancer, fibrosis of the lungs, arteriosclerosis, post myocardial infarction, cardiac fibrosis, post-angioplasty restenosis, renal interstitial fibrosis, scarring and diabetic nephropathy. The present invention further provides methods for treating diabetes and pharmaceutical compositions useful in such methods.
Border Wayne A.
Ruoslahti Erkki I.
Gowling Lafleur Henderson Llp
La Jolla Cancer Research Foundation
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