Inhibiting transforming growth factor .beta. to prevent...

A - Human Necessities – 61 – K

Patent

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A61K 39/395 (2006.01) A61K 38/04 (2006.01) A61K 38/18 (2006.01) A61K 38/39 (2006.01) C07K 14/78 (2006.01) C07K 16/22 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2065860

The present invention provides a method for treating or arresting the progress of pathologies characterized by an accumulation of extracellular matrix components by providing an agent to suppress the activity of transforming growth factor .beta. (TGF-.beta.) a peptide growth factor which is anabolic and leads to fibrosis and angiogenesis. In one embodiment, such agent is anti-TGF-.beta. antibody. Pathologies which can be so treated include the various fibrotic diseases. The invention further provides a method for the diagnosis of pathologies, or incipient pathologies, which are characterized by the accumulation of extracellular matrix components in tissues by determining the levels of TGF-.beta. in the tissues, a high level being indicative of such pathologies.

Procédé de traitement ou d'arrêt de la progression de pathologies caractérisées par une accumulation de composants matriciels extracellulaires, consistant à administrer un agent destiné à supprimer l'activité du facteur beta de croissance à transformation (TGF-beta), un facteur de croissance peptidique, lequel est anabolisant et mène à la fibrose ainsi qu'à l'angiogénèse. Dans un mode de réalisation, ledit agent est un anticorps anti-TGF-beta. Les pathologies pouvant être ainsi traitées comprennent les diverses maladies fibrotiques. L'invention concerne en outre un procédé de diagnostic de pathologies, ou de pathologies naissantes, lesquelles sont caractérisées par l'accumulation de composants matriciels extracellulaires dans des tissus, consistant à déterminer les niveaux de TGF-beta dans les tissus, un niveau élevé révélant lesdites pathologies.

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