Inhibition of 5-lipoxygenase and cyclooxygenase pathway...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/505 (2006.01) C07D 207/333 (2006.01) C07D 233/64 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2084290

2084290 9119497 PCTABS00008 A method of dual inhibition of 5-lipoxygenase pathway mediated diseases and cyclooxygenase pathway mediated diseases in a subject in need thereof which comprises administering to such subject an effective, non-toxic 5-lipoxygenase pathway inhibiting amount or an effective, non-toxic cyclooxygenase pathway inhibiting amount of a diaryl-substituted imidazole fused to a second unsaturated 5 or 6 membered heterocyclic ring containing a nitrogen bridgehead atom wherein said second 5 membered ring also contains a sulfur or oxygen atom or said 6 membered ring may also contain an additional nitrogen atom.

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