Inhibition of alpha-synuclein aggregation

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 7/00 (2006.01)

Patent

CA 2656287

This invention relates to the inhibition of alpha- synuclein aggregation using peptidyl compounds which are retroenantiomers of the alpha- synuclein sequence, in particular retroenantiomers of sequences in the regions between residues 1 to 60 or residues 61 to 96. Peptidyl compounds of the invention may optionally be coupled to doperminergic targeting moieties and/or blood brain barrier transport moieties and may be useful in the treatment of alpha-synucleinopathies such as Parkinson's disease.

La présente invention concerne l'inhibition d'agrégation d'alpha-synucléine en utilisant des composés de peptidyle qui sont des retro-énantiomères de la séquence d'alpha-synucléine, en particulier des rétroénantiomères de séquences dans les zones comprises entre les résidus 1 à 60 ou les résidus 61 à 96. Des composés de peptidyle de l'invention peuvent éventuellement être couplés à des portions cibles doperminergiques et/ou à des portions de transport de la barrière hémato-encéphalique et peuvent être utiles dans le traitement d'alpha-synucléinopathies comme la maladie de Parkinson.

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