Inhibition of an fgf-binding protein using ribozymes

Details Inhibition of an fgf-binding protein using ribozymes Inhibition of an fgf-binding protein using ribozymes

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2304987

Increased expression of a secreted FGF-binding protein (FGF-BP) occurs in certain autoimmune and malignant disease conditions. It is found, for example, that tumor secretions of FGF-BP results in mobilization and activation of locally-stored FGFs that can serve as an angiogenic switch molecule. Furthermore, it has been found that in an animal model of multiple sclerosis (MS), the exacerbation of the disease is accompanied by increased FGF-BP. Using ribozymes, it is possible to cause cleavage of the FGF-BP mRNA. Hence, administration of ribozymes which cleave the FGF-BP mRNA in sufficient amounts to inhibit disease processes triggered by FGF-BP is appropriate.

Dans certaines maladies auto-immunes et malignes, on a observé une augmentation de l'expression des protéines de fixation du facteur FGF (FGF-BP) sécrétées. On a notamment découvert que les sécrétions de protéines de fixation du FGF par les tumeurs entraînent la mobilisation et l'activation de FGF (facteurs de croissance des fibroblastes) stockés localement, qui peuvent servir comme molécule de transition angiogénique. On a découvert en outre que, chez un modèle animal souffrant de sclérose en plaques, l'exacerbation de la maladie s'accompagne d'une augmentation de la protéine FGF-BP. A l'aide de ribozymes, on peut produire le clivage de l'ARNm de la protéine FGF-BP. Par conséquent, l'administration de ribozymes entraînant le clivage de l'ARNm de FGF-BP en quantités suffisantes pour inhiber le processus morbide déclenché par la protéine FGF-BP, est appropriée.

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