Inhibition of angiogenesis by high molecular weight...

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 38/02 (2006.01) A61K 38/03 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 7/18 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2355287

Peptide analogs the high molecular weight kininogen domain (3) are potent inhibitors of angiogenesis. The peptides have the formula (a) X1-Asn-Asn-Ala- Thr-Phe-Tyr-Phe-Lys-X2, (b) X3-Cys-Val-Gly-Cys-X4, (c) X5-Leu-Asp-X7-Asn-Ala- Glu-Val-Tyr-X6, or (d) Tyr-Phe-Ile-Asp-Phe-Val-Ala-Arg-Glu-Thr-Thr-X7-Ser-Lys- Glu-Ser wherein: X1, X2, X3, X4, X5, and X6 are from zero to twelve amino acids, independently the same or different, more preferably from zero to six amino acids, and; X7 is Ala or Cys. The peptides may also comprise biologically active fragments of high molecular weight kininogen domain (3). Methods of inhibiting endothelial cell proliferation and angiogenesis are provided.

L'invention concerne des analogues de peptides du domaine 3 du kininogène à poids moléculaire élevé, qui constituent des inhibiteurs puissants de l'angiogenèse. Les peptides sont représentés par la formule (a) X¿1?-Asn-Asn-Ala-Thr-Phe-Tyr-Phe-Lys-X¿2?, (b) X¿3?-Cys-Val-Gly-Cys-X¿4?, (c) X¿5?-Leu-Asp-X¿7?-Asn-Ala-Glu-Val-Tyr-X¿6?, ou (d) Tyr-Phe-lle-Asp-Phe-Val-Ala-Arg-Glu-Thr-Thr-X¿7?-Ser-Lys-Glu-Ser, dans laquelle X¿1?, X¿2?, X¿3?, X¿4?, X¿5? et X¿6? représentent de zéro à douze acides aminés indépendamment identiques ou différents, et de préférence de zéro à six acides aminés, et X¿7? est Ala ou Cys. Les peptides peuvent également comporter des fragments biologiquement actifs du domaine 3 du kininogène à poids moléculaire élevé. L'invention concerne des procédés permettant d'inhiber la prolifération de cellules endothéliales et l'angiogenèse.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Inhibition of angiogenesis by high molecular weight... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of angiogenesis by high molecular weight..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of angiogenesis by high molecular weight... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1928279

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.