A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/02 (2006.01) A61K 38/03 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 7/18 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2355287
Peptide analogs the high molecular weight kininogen domain (3) are potent inhibitors of angiogenesis. The peptides have the formula (a) X1-Asn-Asn-Ala- Thr-Phe-Tyr-Phe-Lys-X2, (b) X3-Cys-Val-Gly-Cys-X4, (c) X5-Leu-Asp-X7-Asn-Ala- Glu-Val-Tyr-X6, or (d) Tyr-Phe-Ile-Asp-Phe-Val-Ala-Arg-Glu-Thr-Thr-X7-Ser-Lys- Glu-Ser wherein: X1, X2, X3, X4, X5, and X6 are from zero to twelve amino acids, independently the same or different, more preferably from zero to six amino acids, and; X7 is Ala or Cys. The peptides may also comprise biologically active fragments of high molecular weight kininogen domain (3). Methods of inhibiting endothelial cell proliferation and angiogenesis are provided.
L'invention concerne des analogues de peptides du domaine 3 du kininogène à poids moléculaire élevé, qui constituent des inhibiteurs puissants de l'angiogenèse. Les peptides sont représentés par la formule (a) X¿1?-Asn-Asn-Ala-Thr-Phe-Tyr-Phe-Lys-X¿2?, (b) X¿3?-Cys-Val-Gly-Cys-X¿4?, (c) X¿5?-Leu-Asp-X¿7?-Asn-Ala-Glu-Val-Tyr-X¿6?, ou (d) Tyr-Phe-lle-Asp-Phe-Val-Ala-Arg-Glu-Thr-Thr-X¿7?-Ser-Lys-Glu-Ser, dans laquelle X¿1?, X¿2?, X¿3?, X¿4?, X¿5? et X¿6? représentent de zéro à douze acides aminés indépendamment identiques ou différents, et de préférence de zéro à six acides aminés, et X¿7? est Ala ou Cys. Les peptides peuvent également comporter des fragments biologiquement actifs du domaine 3 du kininogène à poids moléculaire élevé. L'invention concerne des procédés permettant d'inhiber la prolifération de cellules endothéliales et l'angiogenèse.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Temple University - Of The Commonwealth System Of Higher Educati
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