Inhibition of angiogenesis, tumorigenesis and cathepsin...

Details Inhibition of angiogenesis, tumorigenesis and cathepsin... Inhibition of angiogenesis, tumorigenesis and cathepsin...

A - Human Necessities

61

K

A61K 38/57 (2006.01) A61K 38/30 (2006.01) A61P 35/00 (2006.01) C07K 14/65 (2006.01) C07K 14/81 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2659585

Insulin-like growth factor binding proteins (IGFBPs) and variants thereof, including IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, IGFBP-6 and the C-terminal fragments thereof, inhibit angiogenesis, tumorigenesis and cathepsin activity, particularly cathepsin B activity.

La présente invention concerne des protéines de liaison au facteur de croissance de type insuline (IGFBP) et des variants de celles-ci, comprenant IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, IGFBP-6 et leurs fragments C-terminal, qui inhibent l'angiogenèse, la tumorigenèse et l'activité de la cathepsine, notamment l'activité de la cathepsine B.

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