Inhibition of antigen presentation with poorly catabolized...

A - Human Necessities – 61 – K

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A61K 31/715 (2006.01) A61K 31/721 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2460042

Methods to prevent the rejection of immunogenic tissues in an animal by administering a non-immunogenic, poorly catabolized molecule in an amount sufficient to inhibit an immune response are described herein. Also described are compositions that are useful for inhibiting immune responses in animals that are recipients of celular transplants. For example, these methods and compositions can be used to prevent the rejection of xenografted and allografted tissues in an animal.

L'invention concerne des méthodes de prévention du rejet de tissus immunogéniques chez un animal par administration d'une molécule non immunogénique faiblement catabolisée en une quantité suffisante pour inhiber une réponse immunitaire. L'invention concerne également des compositions utilisées pour inhiber les réponses immunitaires chez des animaux receveurs de transplants cellulaires. Ces méthodes et ces compositions peuvent être utilisées par exemple pour prévenir le rejet de tissus xénogreffés et allogreffés chez un animal.

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