C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61P 27/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2528372
The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.
La présente invention concerne un facteur d'initiation eucaryote 5A (eIF-5A) spécifique de l'apoptose, appelé eIF-5A spécifique de l'apoptose ou eIF5A1, des acides nucléiques et des polypeptides, ainsi que des méthodes destinées à inhiber ou supprimer l'apoptose dans des cellules au moyen de nucléotides antisens ou de petits ARN interférents en vue d'inhiber l'expression de l'eIF-5A spécifique de l'apoptose. L'invention concerne également la suppression ou l'inhibition de l'expression de cytokines pro-inflammatoires ou l'inhibition de l'activation de NFkB par inhibition de l'expression de l'eIF-5A spécifique de l'apoptose.
Boone Adrienne
Dinarello Charles
Galton Bruce C.
Hopkins Marianne
Reznikov Leonid
Borden Ladner Gervais Llp
Senesco Technologies Inc.
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