Inhibition of apoptosis using interleukin-1.beta.-converting...

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A01N 1/02 (2006.01) A61K 38/55 (2006.01) C07H 21/00 (2006.01) C07K 5/02 (2006.01)

Patent

CA 2265853

The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing bioproduction, using interleukin-1.beta.- converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.

Cette invention se rapporte à des procédés pour accroître des populations de cellules hématopoïétiques et pour en prolonger la survie, afin de prolonger la viabilité d'un organe en vue de sa transplantation et afin d'accroître la bioproduction, en utilisant des inhibiteurs de la famille CED-3/ICE (enzyme de conversion de l'interleukine 1.beta.). Des exemples de composés utiles dans ces procédés sont présentés dans les pièces descriptives de la demande.

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