C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 38/45 (2006.01) A61K 48/00 (2006.01) C12N 15/54 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2184065
A method for inhibiting restenosis associated with mechanical injury of a blood vessel. An adenoviral vector encoding a suicide gene such as thymidine kinase is directly administered to the injured vessel followed by treatment with a nucleotide analog. The analog is phosphorylated converted to a cytotoxin by the suicide gene product, resulting in destruction of the rapidly dividing neointimal cells.
La présente invention concerne l'inhibition de la resténose d'un vaisseau sanguin associée à une blessure mécanique. Le procédé consiste à administrer directement au vaisseau blessé un vecteur adénoviral codant un gène suicide tel que la thymidine kinase puis à poursuivre le traitement avec un analogue nucléotide. Cet analogue est phosphorylaté et converti en une cytotoxine par la production du gène suicide, ce qui provoque la destruction des cellules néointimes à division rapide.
Nabel Elizabeth G.
Nabel Gary J.
Sim & Mcburney
The Regents Of The University Of Michigan
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