Inhibition of attachment of h. influenzae to human cells

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A23C 9/152 (2006.01) A23L 1/305 (2006.01) A61K 38/01 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2190610

The attachment of H.influenza to human cells, such as oropharyngeal cells, may be inhibited by native human .beta.-casein, a recombinant form of human .beta.-casein, and hydrolysates of both. The human .beta.-casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant Formula. The enteral nutritional product may be used, for example, in the prevention and treatment of otitis media in infants. The human .beta.-casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.

La fixation de H. influenzae sur des cellules humaines, telles que les cellules de l'oropharynx, peut être empêchée par la .beta.-caséine humaine native, par une forme recombinée de .beta.-caséine humaine et par des hydrolysats de l'une et de l'autre. La .beta.-caséine humaine ou son hydrolysat peuvent être contenus dans un produit d'alimentation entérale liquide, tel que du lait maternisé. Ce produit d'alimentation entérale peut être utilisé par exemple pour prévenir et traiter l'otite moyenne chez les nourrissons. La .beta.-caséine humaine ou son hydrolysat peuvent également être administrés sous la forme d'un spray pour la gorge ou par voie nasale en gouttes ou en spray.

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