Inhibition of autophagy genes in cancer chemotherapy

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 38/43 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07H 21/02 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2628477

There is provided compositions and methods for improving the therapeutic efficacy of various cancer treatments, for example endocrine therapy, chemotherapy or radiation therapy, by inhibiting the expression of one or more genes involved in the cellular autophagy response. The compositions include compositions comprising an siRNA directed against an Atg gene and may be used to inhibit expression of an Atg gene in a cell currently undergoing cancer therapy, or to treat, inhibit or prevent cancer in a subject in combination with a cancer therapy.

La présente invention concerne des compositions et des procédés pour améliorer l'efficacité thérapeutique de divers traitements contre le cancer, par exemple une endocrinothérapie, une chimiothérapie ou une radiothérapie, en inhibant l'expression d'un ou de plusieurs gènes impliqués dans la réponse d'autophagie cellulaire. Ces compositions comprennent un petit ARN interférent qui est dirigé contre un gène Atg et qui peut être utilisé pour inhiber l'expression d'un gène Atg dans une cellule alors soumise à une thérapie contre le cancer ou pour traiter, inhiber ou prévenir un cancer chez un sujet de manière combinée à une thérapie contre le cancer.

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