Inhibition of bacterial ribonucleotide reductase

Details Inhibition of bacterial ribonucleotide reductase Inhibition of bacterial ribonucleotide reductase

A - Human Necessities

61

K

167/103.05, 530/

A61K 38/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 7/06 (2006.01)

Patent

CA 1337372

Disclosed herein are peptides of the formula Y-R1-R2-R3-R4-R5-R6-R7-R8-R9-Z wherein R1 to R9 are designated amino acid residues; Y is hydrogen or lower alkanoyl, or Y is the hexapeptide radical W- Ile-R10-Ser-R11-Val-R12 wherein W is hydrogen or lower alkanoyl and R10, R11 and R12 are designated amino acid residues, or Y is a fragment of the hexapeptide radical wherein from one to five of the amino acid residues (i.e. Ile to Val) may be deleted serially from the amino terminus of the hexapeptide radical; and Z is hydroxy, amino, lower alkylamino or di(lower alkyl)amino. The peptides inhibit bacterial ribonucleotide reductase and are indicated for preventing or ameliorating bacterial infections.

609873

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