Inhibition of bcl-2 protein expression by liposomal...

Details Inhibition of bcl-2 protein expression by liposomal... Inhibition of bcl-2 protein expression by liposomal...

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61K 9/127 (2006.01) A61K 31/711 (2006.01) A61K 31/7115 (2006.01) A61K 31/7125 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2677176

The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 nucleic acids, the gene products of which are known to interact with the tumorigenic protein Bcl-2. Used alone, or in conjunction with other antisense oligonucleotides, these compositions inhibit the proliferation of FL cancer cells.

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