C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/409 (2006.01) A61K 31/713 (2006.01) A61P 25/28 (2006.01) A61P 27/00 (2006.01)
Patent
CA 2671524
A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase- 1 (HO-I) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrin in a manner that permits access to brain sites and/or the macula of the patient.
La présente invention concerne un procédé de traitement ou d'inhibition de la progression de la démence et/ou de la dégénérescence maculaire chez un mammifère. Ledit procédé implique l'administration de compositions contenant siARN au hème oxygénase-1 (HO-I) ou au hème oxygénase-2 (HO-2), un inhibiteur de métalloprotéase matricielle (MMP), un inhibiteur de caspase, ou une métalloporphyrine, de manière à permettre l'accès à des sites cérébraux et/ou à la macule du patient.
Espina Virginia
Kirsch Wolff
Liotta Lance A.
Van Nostrand William E.
Vinters Harry V.
George Mason University
Loma Linda University Medical Center
Smart & Biggar
Stony Brook University
The Regents Of The University Of California
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