C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/00 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07H 7/02 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2129987
2129987 9317033 PCTABS00025 Many tumor-associated and leukocyte-associated carbohydrate antigens function as adhesion molecules, recognized by lectins (carbohydrate-protein interaction) or complementary carbohydrates (carbohydrate-carbohydrate interaction). Common structures are found in the tumor-associated and leukocyte-associated antigens. Metastatic potential of tumor cells as well as transendothelial migration of leukocytes was suppressed by agents, or combinations of agents of the groups: (a) carbohydrate antigens; (b) antibodies directed to those antigens; (c) oligosaccharide components of those antigens; (d) conjugates of the antigens or oligosaccharides; and (e) mimetics of the antigens or oligosaccharides. Disclosed are oligosaccharides and derivatives thereof which inhibit cell adhesion and aggregation mediated by P-selectin (GMP-140) and E-selectin (ELAM-1). Effective agents for those purposes include hybrid sugars comprising multiple epitopes, such as Lex/SLex, combination of individual sugars that comprise a hybrid sugar, which may be presented on liposomes, and antibodies or combinations of antibodies directed thereto.
Hakomori Sen-Itiroh
Handa Kazuko
Kojima Naoya
Biomembrane Institute (the)
G. Ronald Bell & Associates
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