C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12P 21/00 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2097617
2097617 9209293 PCTABS00013 Disclosed is a method of inhibiting the binding of a cell bearing a cell adhesion protein to a molecule or cell bearing a carbohydrate determinant specific for the cell adhesion molecule. The method involves contacting the cell adhesion protein-bearing cell with an inhibitor molecule bearing the carbohydrate determinant. Also disclosed is a method of inhibiting the binding of the first member of a specific binding pair to the second member of the specific binding pair, involving contacting the first member with an antibody which is specific for the first member and which is covalently bonded to a carbohydrate moiety which interferes with the antibody's ability fo fix complement and bind an Fc receptor. The methods of the invention may be used, for example, to reduce inflammation.
Seed Brian
Walz Gerd
Kirby Eades Gale Baker
The General Hospital Corporation
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