A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/70 (2006.01) A61K 31/715 (2006.01) A61K 38/47 (2006.01) A61K 38/51 (2006.01) C07K 16/18 (2006.01) C12N 9/26 (2006.01)
Patent
CA 2071898
ABSTRACT OF THE DISCLOSURE The present invention is directed to methods of using keratan sulfate, chondroitin sulfate, dermatan sulfate, heparin sulfate, heparin, and hyaluronic acid, and molecules and compositions comprising keratan sulfate, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin, and hyaluronic acid, to inhibit or prevent neurite outgrowth, i.e., axonal growth, or nerve regeneration (colectively termed herein "nerve growth"), or glial cell migration or invasion, or regeneration, and therapeutically, where the foregoing is desired. In another embodiment of the invention, inhibitors and antagonists of keratan sulfate, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin, and hyaluronic acid, and molecules and compositions containing the same, may be used to promote nerve growth or glial cell migration or invasion, and can be administered therapeutically. Such inhibitors and antagonists include but are not limited to antibodies, degradative enzymes, lectins; and disaccharide antagonists of the receptors for keratan sulfate, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin or hyaluronate.
Harel Adrian
Roufa Dikla
Silver Jerry
Snow Diane M.
Case Western Reserve University
Gliatech Inc.
Osler Hoskin & Harcourt Llp
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