Inhibition of cell migration with synthetic peptides

Details Inhibition of cell migration with synthetic peptides Inhibition of cell migration with synthetic peptides

G - Physics

01

N

167/45, 167/103.

G01N 33/574 (2006.01) C07K 14/78 (2006.01) G01N 33/566 (2006.01)

Patent

CA 1324954

ABSTRACT OF THE INVENTION A method of inhibiting the invasion of cells, particularly malignant cells through an extracellular membrane by contacting the membrane-cell interface with synthetic Image peptides. In one embodiment, the invention provides peptides containing the amino acid sequence Image , more specifically Image , which inhibits the attachment of cells to type I collagen in addition to fibronectin and vitronectin, and a method of inhibiting the attachment of cells to type I collagen. The invention further provides an assay for quantitating the invasive quality of cells by determining the amount of such peptides necessary to prevent the cells from penetrating an extracellular membrane, such as an amniotic membrane, in vitro.

591334

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