A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/04 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61P 35/00 (2006.01) C07K 5/08 (2006.01) C07K 5/093 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2387922
Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. The present invention further provides methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking HGF, VEGF, or bFGF- stimulated migration, cell proliferation, and formation of capillary-like structures.
Procédés permettant d'inhiber la motilité cellulaire, par exemple par inhibition de la liaison entre un transducteur intracellulaire et un récepteur de type protéine tyrosine kynase, et plus particulièrement par inhibition de la motilité cellulaire induite par le facteur de croissance des hépatocytes (HGF). La présente invention concerne également des procédés d'inhibition de l'angiogenèse. Les procédés selon la présente invention reposent sur des peptides tels que des mimes phosphotyrosyl. La présente invention concerne en outre des méthodes de prévention ou de traitement de maladies, troubles ou états pathologiques tels que le cancer, en particulier le cancer métastatique, qui consistent à administrer à un mammifère atteint un ou plusieurs peptides selon la présente invention. Des procédés de blocage de la migration, de la prolifération cellulaire et de la formation de structures de type capillaire stimulées par HGF, VEGF ou bFGF sont également décrits.
Atabey Safiye N.
Bottaro Donald P.
Breckenridge Diane E.
Burke Terrence R. Jr.
Gao Yang
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
R. William Wray & Associates
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