Inhibition of coagulation in blood and blood products

Details Inhibition of coagulation in blood and blood products Inhibition of coagulation in blood and blood products

C - Chemistry, Metallurgy

12

Q

C12Q 1/56 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2333890

The present invention provides methods for inhibiting blood clotting. In general, the methods include adding corn trypsin inhibitor (CTI) to blood or a blood product in an amount sufficient to inhibit the clotting. The CTI can be used alone or in combination with other anti-coagulants. In one aspect, the invention features plasma clotting assays featuring substantially prolonged clotting times. Clotting assays using whole or minimally altered blood are also provided. Further provided are methods for storing blood or blood products at low temperature with the CTI.

L'invention porte sur un procédé évitant la coagulation du sang consistant en général dans l'adjonction d'un inhibiteur de la trypsine du blé (CTI) à du sang ou à un produit sanguin en quantité suffisante pour empêcher la coagulation. Le CTI peut s'utiliser seul ou en association avec d'autres anticoagulants. L'un des aspects de l'invention a trait à des essais faisant état de temps de coagulation notablement prolongés et en particulier sur des essais sur du sang entier ou très peu altéré. L'invention porte en outre sur des procédés de stockage de sang ou de produits sanguins à basse température recourant au CTI.

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