Inhibition of dr3 in the treatment of allergic lung...

A - Human Necessities – 61 – K

Patent

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A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2536086

The invention provides a method of modulating a T cell immune response by modulating DR3 function in the T cell, wherein the T cell response causes a symptom of inflammatory lung disease. The invention also provides a method of treating a reactive airway disease in an animal subject by administering to the subject an agent which modulates at least one functional activity of CD30. The invention additionally provides a method for treating an inflammatory lung disease by administering an agent that decreases the activity of DR3 or CD30, whereby IL-13 expression is decreased.

La présente invention a trait à un procédé de modulation d'une réponse immunitaire du lymphocyte T par la modulation de la fonction DR3 dans le lymphocyte T, dans lequel la réponse du lymphocyte T provoque un symptôme de la maladie pulmonaire inflammatoire. L'invention a également trait à un procédé de traitement d'une maladie bronchique réactive chez un animal par l'administration au sujet d'un agent modulateur d'au moins une activité fonctionnelle de CD30. L'invention a trait en outre à un procédé pour le traitement de la maladie pulmonaire inflammatoire par l'administration d'un agent qui réduit l'activité de DR3 ou de CD30, grâce à quoi l'expression de IL-13 est réduite.

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