C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/19 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01) C12N 15/81 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2513182
Human HAKAI (hsHAKAI), an E3-ubiquitin ligase, can be inhibited to treat proliferative disorders, such as cancers, dysplasias and hyperplasias. Effective levels of hsHAKAI can be inhibited, for example, using antisense oligonucleotides, ribozymes, interference RNA, and antibodies. Test compounds can be screened for binding to hsHAKAI, for disruption of hsHAKAI-E-cadherin binding, or for inhibition of hsHAKAI enzymatic activity to identify therapeutic compounds for treating proliferative disorders.
L'invention concerne HAKAI humaine (hsHAKAI), une E3-ubiquitine ligase, qui peut être inhibée dans le but de traiter des troubles à évolution chronique, tels que les cancers, les dysplasies et les hyperplasies. Des taux effectifs de hsHAKAI peuvent être inhibés, par exemple, au moyen d'oligonucléotides antisens, de ribozymes, d'ARN d'interférence et d'anticorps. Des composés test peuvent être criblés pour liaison à hsHAKAI, pour disruption de la liaison hsHAKAI-E-cadhérine, ou pour inhibition de l'activité enzymatique de hsHAKAI, afin d'identifier des composés thérapeutiques destinés au traitement de troubles à évolution chronique.
Reinhard Christoph
Walter Annette O.
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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