Inhibition of endothelin-1 to reduce inflammatory processes

Details Inhibition of endothelin-1 to reduce inflammatory processes Inhibition of endothelin-1 to reduce inflammatory processes

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 38/03 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/575 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2199939

The vasoactive and mitogenic peptide, endothelin-1 (ET-1) is upregulated within grafts, and methods of diagnosing and treating graft rejection, arteriosclerosis, and other cell-mediated inflammatory conditions are provided. These methods involve identifying and reducing expression of ET-1.

La production du peptide vasoactif et mitogène qu'est l'endothéline-1 (ET-1) est stimulée dans les greffes. L'invention concerne des procédés pour diagnostiquer et traiter les rejets de greffes, l'artériosclérose et d'autres inflammations à médiateurs cellulaires. Ces procédés consistent à déterminer le niveau d'expression de l'ET-1, et à le réduire.

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