C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
195/71, 530/7.1,
C07K 14/435 (2006.01) A01N 63/02 (2006.01) A61K 38/17 (2006.01) A61K 38/47 (2006.01) C12N 1/06 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 1340716
Inhibition of eucaryotic pathogens and neoplasms and stimulation of lymphocytes and fibroblasts with lytic peptides such as cecropins and sarcotoxins. Eucaryotic cells are contacted with cecropin or sarcotoxin, or a synergistic combination of cecropins or sarcotoxin with lysozyme, in an amount effective to lyse or inhibit the cells. Target cells include eucaryotic microorganisms such as protozoa, e.g. T. cruzi and P. falciparum, mammalian lymphomas and leukemias, and cells infected with intracellular pathogens such as viruses, bacteria and protozoa. Also disclosed is a method for stimulating proliferation of lymphocytes and fibroblasts by contacting such cells with an effective amount of cecropin or sarcotoxin. The methods may be in vitro or in vivo.
578682
Enright Frederick M.
Jaynes Jesse M.
Jeffers Gale
White Kenneth L.
Enright Frederick M.
Helix Biomedix Inc.
Jaynes Jesse M.
Jeffers Gale
Kirby Eades Gale Baker
LandOfFree
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