Inhibition of exoprotein production using aromatic compositions

Details Inhibition of exoprotein production using aromatic compositions Inhibition of exoprotein production using aromatic compositions

A - Human Necessities

61

L

A61L 15/46 (2006.01)

Patent

CA 2461291

Absorbent and non-absorbent articles are disclosed. The articles include an effective amount of an aromatic inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria. The aromatic inhibitory compounds of the present invention have the general formula (I), wherein R1 is selected from the group consisting of H, (a), -OR5, -R6C(O)H, -R6OH, -R6COOH, - OR6OH, -OR6COOH, -C(O)NH2, formula (1) and NH2 and salts thereof; R5 is a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety; R6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety; R7 is a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety; R8 is a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms; R2, R3, and R4 are independently selected from the group consisting of H, OH, COOH, and -C(O)R9; R9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety.

L'invention concerne des articles absorbants et non absorbants. Ces articles comprennent une quantité efficace d'un composé aromatique inhibiteur destiné à inhiber sensiblement la production d'exotoxines par des bactéries gram positif. Les composés aromatiques inhibiteurs de la présente invention sont représentés par la formule générale (I), dans laquelle R?1¿ est sélectionné dans le groupe composé de H, (a), -OR?5¿, -R?6¿C(O)H, -R?6¿OH, -R?6¿COOH, -OR?6¿OH, -OR?6¿COOH, -C(O)NH¿2?, et NH¿2? et les sels de ceux-ci; R?5¿ est un fragment hydrocarbyle aliphatique monovalent saturé ou non saturé; R?6 ¿est un fragment hydrocarbyle aliphatique divalent saturé ou non saturé; R?7 ¿est un fragment hydrocarbyle aliphatique trivalent saturé ou non saturé; R?8¿ est un fragment hydrocarbyle aliphatique monovalent saturé ou non saturé substitué ou non substitué pouvant ou ne pouvant pas être interrompu par des hétéroatomes; R?2¿, R?3¿ et R?4¿ sont indépendamment sélectionnés dans le groupe composé de H, OH, COOH, et -C(O)R?9¿; et R?9 ¿est hydrogène ou un fragment hydrocarbyle aliphatique monovalent saturé ou non saturé.

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