Inhibition of expression of beta-lactamase using esters of...

Details Inhibition of expression of beta-lactamase using esters of... Inhibition of expression of beta-lactamase using esters of...

A - Human Necessities

61

K

A61K 31/43 (2006.01) A61K 31/23 (2006.01) A61K 31/545 (2006.01)

Patent

CA 2162601

A class of chemical compounds comprising fatty acid ester derivatives used to inhibit beta-lactamase production by infectious bacteria. These inhibitors have been found to retard the resistance of certain strains of bacteria to beta-lactam antibiotics, such as penicillin, by interfering with the transcription of the beta-lactamase gene and precluding expression of beta-lactamase. In accordance therewith, therewith, these inhibitors permit effective treatment of infections of otherwise resistive bacteria with antibiotics.

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