A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2561531
Disclosed are novel inhibitors of the alternative complement pathway and particularly, novel anti-factor B antibodies. Also disclosed is the use of such inhibitors to reduce or prevent airway hyperresponsiveness and/or airway inflammation by selectively inhibiting the alternative complement pathway, thereby treating diseases in which such conditions play a role. Also disclosed is the use of such inhibitors to reduce or prevent other diseases and conditions, including ischemia-reperfusion injury, by inhibition of the alternative complement pathway.
L'invention concerne de nouveaux inhibiteurs de la voie du complément alternative, en particulier de nouveaux anticorps anti-facteur B. L'invention concerne également l'utilisation de ces inhibiteurs dans l'atténuation ou la prévention de l'hypersensibilité des voies aériennes et/ou des inflammations des voies aériennes, par l'inhibition sélective de la voie du complément alternative, ce qui permet de traiter les maladies dans lesquelles ces états jouent un rôle. L'invention concerne également l'utilisation de ces inhibiteurs dans l'atténuation ou la prévention d'autres maladies ou états, notamment les lésions d'ischémie-reperfusion, par l'inhibition de la voie du complément alternative.
Gelfand Erwin W.
Gilkeson Gary Steven
Holers Vernon Michael
Taube Christian
Thurman Joshua M.
Heenan Blaikie Llp
Musc Foundation For Research Development
National Jewish Medical And Research Center
The Regents Of The University Of Colorado
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