Inhibition of graft versus host disease

Details Inhibition of graft versus host disease Inhibition of graft versus host disease

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 38/19 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2244554

The development of graft versus host disease in a mammalian patient undergoing cell transplantation therapy for treatment of a bone marrow mediated disease, is prevented or alleviated by subjecting at least the T-cells of the allogeneic cell transplantation composition, extracorporeally, to at least one stressor selected from heat stressors and oxidative stressors, in appropriate dosage amounts. A preferred process involves subjecting composition including T-cells and stem cells to the stressor(s) in the presence of a stem cell growth factor which acts as a protectant for the stem cells during the stressing process.

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